KCET · BIOLOGY · STD 12 - 4. Principles of Inheritance and Variation

Replacement of which one of the following nucleotides in the \(Hb ^{ A }\) gene causes sickle cell anaemia?

A A to T
B T to A
C U to A
D C to G

Verified Solution

Answer & Solution

Correct Answer

(A) A to T

Step-by-step Solution

Detailed explanation

(A) A to T,
A mutation in one of the base from an A to a T of the gene coding for glutamic acid in the DNA, charges the amino acid from glutamic acid to valine at the same position.

Apply the relevant identity from the chapter and substitute the values established in the previous step, keeping the original constraint in view.

Use the simplified expression to isolate the unknown, then plug the result back into the question setup to confirm the working is internally consistent.

Cross-check against a boundary or limiting case. Both the dimensional balance and the qualitative behaviour at the extreme should agree with the candidate answer.

Combine the steps above to identify the correct option. The remaining choices each fail at least one of the consistency, dimensional, or boundary checks.

Same subject

Explore more questions on app

From KCET

Explore more questions on app