Which one of the following is not applicableto \(RNA\) ?

A Heterocyclic nitrogenous bases
B Chargaff’s rule
C Complementary base pairing
D \(5’ \) phosphoryl and \(3’\) hydroxyl ends

Verified Solution

Answer & Solution

Correct Answer

(B) Chargaff’s rule

Step-by-step Solution

Detailed explanation

(b) : Chargaff’s rules are applicable only for double stranded \(DNA\) molecule. These are not applicable for single stranded \(DNA\) or \(RNA\) molecules. Chargaff’s rules state that \(DNA\) helices contain equal molar ratios of \(A\) and \(T, G \) and \(C\). This is because in a ds \(DNA\) molecule, complementary base pairing occurs between \(A\) and \(T\), and \(C\) and \(G\) base pairs. This complementary base pairing is not possible in case of single stranded \(RNA\) molecule. Thus, Chargaff’s rules are not applicable to \(RNA\).

Apply the relevant identity from the chapter and substitute the values established in the previous step, keeping the original constraint in view.

Use the simplified expression to isolate the unknown, then plug the result back into the question setup to confirm the working is internally consistent.

Cross-check against a boundary or limiting case. Both the dimensional balance and the qualitative behaviour at the extreme should agree with the candidate answer.

Combine the steps above to identify the correct option. The remaining choices each fail at least one of the consistency, dimensional, or boundary checks.

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