The following are the stages of life cycle of Plasmodium. Arrange the stages in the proper order.
A. The parasites reproduce asexually in RBCs, bursting the cells.
B. The parasites reproduce asexually in liver cells, bursting the cells and releasing into blood.
C. Gametocytes develop in RBCs.
D. Sporozoites reach the liver through the blood.
E. Female mosquito injects sporozoites into humans during bite.
Choose the correct answer from the options given below :

(A) E, D, B, A, C
The life cycle of Plasmodium in the human body follows a specific sequence:
First, an infected female Anopheles mosquito bites a human and injects the infective form, known as sporozoites, into the human body (E).
These sporozoites travel through the bloodstream and reach the liver (D).
Inside the liver cells, the parasites multiply asexually, eventually bursting the liver cells and releasing the newly formed parasites (merozoites) into the blood (B).
The released parasites then enter the red blood cells (RBCs) where they continue to reproduce asexually. This causes the RBCs to burst, releasing toxic substances (hemozoin) responsible for the characteristic chills and high fever (A).
Finally, some of the parasites in the RBCs differentiate into the sexual stages called gametocytes (C), which are later taken up by a mosquito during a blood meal to continue the cycle.
Thus, the correct sequence is E, D, B, A, C.