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NEET · Biology · STD 12 - 5. molecular basis of inheritance

The association of histone \(H_1\) with a nucleosome indicates that

  1. A \(DNA\) replication is occurring
  2. B the \(DNA\) is condensed into a chromatin fibre
  3. C the \(DNA\) double helix is exposed
  4. D transcription is occurring.
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Answer & Solution

Correct Answer

(B) the \(DNA\) is condensed into a chromatin fibre

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Detailed explanation

(b) : Histones help in packaging of \(DNA\). In eukaryotes, \(DNA\) packaging is carried out with the help of positively charged basic proteins called histones. Histones are of five types -\(H_1, H_2A, H_2B,H_3\) and \(H_4\). \(H_1\) is attached over the linker \(DNA\). Histone contains a large proportion of the positivelycharged (basic) amino acids, lysine and arginine in their structure. \(DNA\) is negatively charged due to the phosphate groups on its backbone. The result of these opposite charges is strong attraction and therefore, high binding affinity between histones and \(DNA\).
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