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NEET · Biology · STD 12 - 4. principal of inheritance and variation
Select the incorrect statement with regard to haemophilia.
- A It is a dominant disease.
- B A single protein involved in the clotting of blood is affected.
- C It is a sexlinked disease.
- D It is a recessive disease.
Answer & Solution
Correct Answer
(A) It is a dominant disease.
Step-by-step Solution
Detailed explanation
(a): Haemophilia is sexlinked disease which is also known as bleeder’s disease as the patient will continue to bleed even from a minor cut since he or she does not possess the natural phenomenon of blood clotting due to absence of antihaemophiliac globulin or factor \(VIII\) (haemophilia -\(A\)) and plasma thromboplastin factor \(IX\) (haemophilia-\(B\), Christmas disease) essential for it. As a result of continuous bleeding the patient may die of blood loss. It is geneticallydue to the presence ofa recessive sex linked gene \(h\), carried by \(X\)-chromosome. A female becomes haemophiliac only when both of her \(X\)-chromosomes carry the gene \((X^hX^h)\). However, such females generally die before birth because the combination of these two recessive alleles is lethal. A female having only one allele for haemophilia \((XX^h)\) appears normal because the allele for normal blood clotting present on the other Xchromosome is dominant. Such females are known as carriers. In case of males, a single gene for the defect is able to express itself as the \(Y\) chromosome is devoid of any corresponding allele \((X^hY)\).
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