MHT CET · Chemistry · Biomolecules

Which from following statements is NOT true for nucleic acids?

A 5' end of polynucleotide has free phosphate group.
B Nucleic acids contain back bone formed of \(-\mathrm{C}-\mathrm{O}-\mathrm{C}-\) linkage.
C Polynucleotide has free -OH group at \(3^{\prime}\) end.
D Neighbouring nucleotides are bonded through phosphate diester linkage.

Verified Solution

Answer & Solution

Correct Answer

(B) Nucleic acids contain back bone formed of \(-\mathrm{C}-\mathrm{O}-\mathrm{C}-\) linkage.

Step-by-step Solution

Detailed explanation

Option B is NOT true for nucleic acids.
In nucleic acids, the backbone is formed by a sugar-phosphate linkage rather than a \(-\mathrm{C}-\mathrm{O}-\mathrm{C}-\) linkage. The backbone is composed of alternating sugar and phosphate groups, connected by phosphodiester bonds. Each phosphate group links the \(3^{\prime}\) carbon atom of one sugar molecule to the \(5^{\prime}\) carbon atom of the next sugar molecule, which forms the characteristic sugar-phosphate-sugar chain of DNA and RNA.

Apply the relevant identity from the chapter and substitute the values established in the previous step, keeping the original constraint in view.

Use the simplified expression to isolate the unknown, then plug the result back into the question setup to confirm the working is internally consistent.

Cross-check against a boundary or limiting case. Both the dimensional balance and the qualitative behaviour at the extreme should agree with the candidate answer.

Combine the steps above to identify the correct option. The remaining choices each fail at least one of the consistency, dimensional, or boundary checks.

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