MHT CET · BIOLOGY · STD 12 - 12. Biotechnology

Which one of the following disorder CANNOT be treated by gene therapy?

A Gaucher's disease
B Haemophilia
C Sickle cell anaemia
D Down's syndrome

Verified Solution

Answer & Solution

Correct Answer

(D) Down's syndrome

Step-by-step Solution

Detailed explanation

i. Gene therapy is the treatment of disease (disorder) by replacing, altering or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for the disease (disorder).
ii. Down's syndrome is a chromosomal disorder. The root cause is an entire extra chromosome, not a single gene defect.

Apply the relevant identity from the chapter and substitute the values established in the previous step, keeping the original constraint in view.

Use the simplified expression to isolate the unknown, then plug the result back into the question setup to confirm the working is internally consistent.

Cross-check against a boundary or limiting case. Both the dimensional balance and the qualitative behaviour at the extreme should agree with the candidate answer.

Combine the steps above to identify the correct option. The remaining choices each fail at least one of the consistency, dimensional, or boundary checks.

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