KCET · BIOLOGY · STD 12 - 4. Principles of Inheritance and Variation
Sickle-cell anaemia is due to the following mutant gene
- A CTC-CAC
- B CTC-GAC
- C CAC-GUG
- D GAG-GUG
Answer & Solution
Correct Answer
(A) CTC-CAC
Step-by-step Solution
Detailed explanation
(A) CTC-CAC,
In the case of sickle cell anemia, the substitution of valine (CTC) for glutamic acid (CAC) at the sixth position in the ẞ chain allows a new bond to form, which changes the conformation of the haemoglobin and leads to aggregation of haemoglobin molecules. This is an example of silent point mutation.
In the case of sickle cell anemia, the substitution of valine (CTC) for glutamic acid (CAC) at the sixth position in the ẞ chain allows a new bond to form, which changes the conformation of the haemoglobin and leads to aggregation of haemoglobin molecules. This is an example of silent point mutation.
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