Oxidative decarboxylation occurs during the formation of

(C) acetyl CoA and succinyl CoA,
Oxidative decarboxylation occurs during the formation of both acetyl CoA from pyruvate and succinyl CoA from \(\alpha\)-ketoglutarate. In these reactions, a carboxyl group is removed as \(CO _2\), and \(NAD ^{+}\)is reduced to NADH. These steps are key parts of cellular respiration, particularly in the link reaction (pyruvate to acetyl CoA ) and the Krebs cycle ( \(\alpha\)-ketoglutarate to succinyl CoA).
1. \(\text { Pyruvate }+CoA+ NAD^{+} \longrightarrow \text { Acetyl } CoA+CO_2+NADH+H^{+}\)
This reaction is catalyzed by the enzyme pyruvate dehydrogenase.
2. \(\alpha\)-Ketoglutarate \(+ CoA + NAD ^{+} \longrightarrow\)
Succinyl \(CoA + CO _2+ NADH + H ^{+}\)
This reaction is catalyzed by the enzyme a-ketoglutarate dehydrogenase.