The first clinical gene therapy was given in 1990 to a 4-year-old girl with ___________ .

Match List I with List II.

LIST I	LIST II
A. Artificial insemination	I. Infertility
B. Chromosomal disorder	II. Assisted Reproductive Technologies
C. Gonorrhoea	III. Amniocentesis
D. Inability to produce children	IV. Sexually transmitted infections

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Read the following paragraph and answer the given questions.
RNAi takes place in all eukaryotic organisms as a method of cellular defense. The source of this complementary RNA could be from an infection by viruses having RNA genomes or mobile genetic elements (transposons) that replicate via an RNA intermediate. Insulin from an animal source, though caused some patients to develop allergy or other types of reactions to the foreign protein. Insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulphide bridges. Transgenic mice are being developed for use in testing the safety of vaccines before they are used on humans. Transgenic mice are being used to test the safety of the polio vaccine. If successful and found to be reliable, they could replace the use of monkeys to test the safety of batches of the vaccine. Specific Bt toxin genes were isolated from Bacillusthuringiensis} and incorporated into the several crop plants such as cotton. The choice of genes depends upon the crop and the targeted pest, as most Bt toxins are insect-group specific. The toxin is coded by a gene cryIAc named cry. There are a number of them, for example, the proteins encoded by the genes cryIAc and cryIIAb control the cotton bollworms, that of cryIAb controls corn borer.

The suitable example of mobile genetic elements is:

Match List - I with List - II.

List - I	List - II
(A) Cyclosporin A	(I) Lowers blood cholesterol
(B) Streptokinase	(II) Citric acid
(C) Aspergillus niger	(III) Immunosuppressant
(D) Statin	(IV) Clot buster

Choose the correct answer from the options given below :

Match List I with List II

LIST I	LIST II
A. Funnel-shaped part of oviduct, closer to the ovary	I. Isthmus
B. The last part of the oviduct	II. Ampulla
C. Finger-like projections at the edges of funnel shaped part of the oviduct	III. Infundibulum
D. Broad and middle part of the oviduct	IV. Fimbriae

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Who popularised the term 'Biodiversity' that intends to describe the combined diversity at all the levels of biological organisation?

Arrange the following events of the menstrual cycle in the correct
sequence:
(A) The rising level of FSH stimulates the growth of the ovarian follicle and
secretion of estrogen.
(B) The corpus luteum secretes progesterone to maintain the endometrium.
(C) The rapid secretion of LH leads to the rupturing of the Graafian follicle.
(D) The release of unfertilized secondary oocyte leads to the menstrual
cycle.
Choose the correct answer from the options given below:

Match List I with List II

LIST I	LIST II
A. Transducer	I. High frequency wave
B. Modulated Waves	II. Receiver
C. Band width	III. Provides output in electrical form
D. Demodulator	IV. Range of frequencies over which communication system works.

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Read the following paragraph and answer the given questions:
DRUGS AND ALCOHOL ABUSE
The drugs, commonly abused are opioids, cannabinoids, and coca alkaloids. Opioids are the drugs, which bind to specific opioid receptors present in our central nervous system and gastrointestinal tract. Heroin, commonly called smack is chemically diacetylmorphine which is a white, odourless, bitter crystalline compound. Cannabinoids are a group of chemicals, which interact with cannabinoid receptors present principally in the brain. Natural cannabinoids are obtained from the inflorescences of the plant Cannabis sativa. The flower tops, leaves and the resin of cannabis plant are used in various combinations to produce marijuana, hashish, charas and ganja. Generally taken by inhalation and oral ingestion, these are known for their effects on cardiovascular system of the body. It interferes with the transport of the neuro-transmitter dopamine. Cocaine, commonly called coke or crack is usually snorted. It has a potent stimulating action on central nervous system, producing a sense of euphoria and increased energy. Excessive dosage of cocaine causes hallucinations. Other well-known plants with hallucinogenic properties are Atropa belladona and Datura. These days cannabinoids are also being abused by some sportspersons. Drugs like barbiturates, amphetamines, benzodiazepines, and other similar drugs, that are normally used as medicines to help patients cope with mental illnesses like depression and insomnia, are often abused. Morphine is a very effective sedative and painkiller, and is very useful in patients who have undergone surgery. Several plants, fruits and seeds having hallucinogenic properties have been used for hundreds of years in folk-medicine, religious ceremonies and rituals all over the globe.
'Coca alkaloids' are obtained from the plant-

If \(\int_0^1 \frac{e^x}{1+x} d x=K\), then \(\int_0^1 \frac{e^x}{(1+x)^2} d x\) is equal to:

When a potential difference is applied across a copper wire, the drift velocity of the electrons is v. If the same potential difference is applied across another copper wire of the same length but twice the diameter, the drift velocity of electrons will be

Read the passage carefully to answer the questions given below
Some strains of `Bacillus thuringiensis` produce proteins that kill certain insects such as lepidopterans (tobacco budworm, armyworm), coleopterans (beetles) and dipterans (flies, mosquitoes). In `Bacillus thuringiensis` the toxin is coded by a gene `crylAc` named cry. There are a number of them, for example, the proteins encoded by the genes `crylAc` and `cryllAb` control the cotton bollworms, that of `crylAb` controls corn borer. Using conventional methods of diagnosis (serum and urine analysis, etc.) early detection is not possible. Recombinant DNA technology, Polymerase Chain Reaction (PCR) and Enzyme Linked Immuno-sorbent Assay (ELISA) are some of the techniques that serve the purpose of early diagnosis. The first clinical gene therapy was given in 1990 to a 4-year old girl with adenosine deaminase (ADA) deficiency. This enzyme is crucial for the immune system to function. The disorder is caused due to the deletion of the gene for adenosine deaminase. `RNAi` takes place in all eukaryotic organisms as a method of cellular defense. This method involves silencing of a specific mRNA due to a complementary `dsRNA` molecule that binds to and prevents translation of the `mRNA`.
Some strains of `Bacillus thuringiensis` produce proteins that do not kill ceratin organisms -

Which of the following statements is NOT CORRECT.