Read the following paragraph and answer the given questions.
RNAi takes place in all eukaryotic organisms as a method of cellular defense. The source of this complementary RNA could be from an infection by viruses having RNA genomes or mobile genetic elements (transposons) that replicate via an RNA intermediate. Insulin from an animal source, though caused some patients to develop allergy or other types of reactions to the foreign protein. Insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulphide bridges. Transgenic mice are being developed for use in testing the safety of vaccines before they are used on humans. Transgenic mice are being used to test the safety of the polio vaccine. If successful and found to be reliable, they could replace the use of monkeys to test the safety of batches of the vaccine. Specific Bt toxin genes were isolated from Bacillusthuringiensis} and incorporated into the several crop plants such as cotton. The choice of genes depends upon the crop and the targeted pest, as most Bt toxins are insect-group specific. The toxin is coded by a gene cryIAc named cry. There are a number of them, for example, the proteins encoded by the genes cryIAc and cryIIAb control the cotton bollworms, that of cryIAb controls corn borer.

Identify the incorrect fact about the genetic modification?

1. A It has made crops more tolerant to abiotic stresses (cold, drought, salt, heat).
2. B It has helped to reduce post harvest losses.
3. C It has decreased the nutritional value of food, e.g., golden rice, i.e., Vitamin 'A' enriched rice.
4. D It has reduced reliance on chemical pesticides (pest-resistant crops).